A cocrystals can be described as a crystalline structure formed by two different or more molecular entities wit weak attractive forces. In crystal engineering, cocrystals technology is an efficient way to modify the character of drugs in solid state and has great potential for improving the physicochemical inadequacies of a drug, such as poor aqueous solubility. Cocrystallization is an emerging stratagem to produce drug substances with desirable preoperties and has remained largely unexplored till recent times. This review go over this highly up-and-coming cocrystals technology, covering basic concepts, cocrystal design and screening, conformer selection, methods of cocrystal preparation and charecterization, applications, scaleup and IPR issues.
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